| abstract |
Novel 6-aryl-5,6-dihydroimidazo[2,1-b]thiazole derivatives of formula <CHEM> wherein Ar is phenyl optionally substituted with halo, hydroxy, C1-6alkyloxy, mercapto, C1-6alkylthio, C1-6alkyl, nitro, amino, mono- and di(C1-6alkyl)amino, C1-6alkylcarbonylamino, arylcarbonylamino, C1-6alkylsulfonylamino, trifluoromethyl, cyano, aminocarbonyl, mono- and di(C1-6alkyl)aminocarbonyl, hydroxycarbonyl, C1-6alkyloxycarbonyl, carboxaldehyde or hydroxymethyl; pyridinyl; thienyl; furanyl or furanyl substituted with either C1-6alkyl or halo; R<1> and R<2> are C1-20alkyl, (C3-7cycloalkyl)C1-6alkyl, C3-7cycloalkyl, aryl or (aryl)C1-6alkyl; one of R<1> and R<2> may by hydrogen; or R<1> and R<2> taken together may form a C3-6alkanediyl radical; the acid addition salts and stereochemically isomeric forms thereof, said compounds having immunostimulating properties. Pharmaceutical compositions containing such compounds as active ingredient. Processes of preparing said novel compounds and pharmaceutical compositions. |