| abstract |
PURPOSE: To prepare a pharmaceutical composition useful for prevention and treatment of AIDS by including dibenz[6,f][1,4]oxazepin(and -thiazepin)-11(10H)- ones or -thiones. n CONSTITUTION: The objective composition is obtained by mixing a compound of the formula (X is O or S; Z is O or S; R 1 is H, a 1-6C alkyl, a 2-6C fluoroalkylmethyl having 1 to 3Fs, etc.; R 2 is H, methyl or a halogen; R 3 is H, a 1-4C alkyl, a halogen, etc.; R 4 is H, methyl or a halogen; R 5 is H, a 1-4C alkyl, hydroxyl, etc.) or a salt thereof, and a pharmaceutically acceptable additive, and the objective medical preparation is obtained therefrom by a conventional method. The composition can be formed into a tablet, a capsule, a solution, a suspension, a suppository, etc. The daily dose of the compound of the formula is 10-500mg in oral administration. The compound of the formula is included in 1-50mg in the preparation for the parenteral administration and a preparation containing 0.01-1wt.% active ingredient is preferable in the topical administration. The large majority of the compound of the formula is well known but some thereof are new. n COPYRIGHT: (C)1991,JPO |