| abstract |
NEW MATERIAL: A compound of formula I [R is H or alkyl; R 1 is H, OH, NH-C(=O)H, -C(=O)NH 2 , NH-C(=O)NH 2 , NHSO 2 R 2 (R 2 is alkyl or optionally substd. phenyl) or halogen; m is 0-6; n is 1-10] and its salt. n EXAMPLE: (R)-2(3,4-Dihydroxybenzyl)1-[5-(N-(3,4dihydroxyphenethyl)-N- propylamino) pentyl] pyrrolidine. n USE: Dopamine agonists useful for treatment of hypertension, congestive heart failure, acute and chronic renal insufficiency, angina, and hyperprolactinemia. n PROCESS: A 2-benzylpyrrolidine of formula II is condensed with an N-(ω- haloalkanoyl)phenethylamine of formula III to give a compound of formula IV, which is then reduced to obtain the compound of formula I. n COPYRIGHT: (C)1991,JPO |