| abstract |
PURPOSE: To prepare a drug for regression or stabilization of atherosclerosis of coronary artery comprising an angiotensin converting enzyme inhibitor (ACE inhibitor). n CONSTITUTION: This drug comprises an ACE inhibitor, especially a mercapto- containing ACE inhibitor (e.g. captopril or zofenopril) and is effective against the regression of atherosclerosis of the coronary artery (reduction and/or deletion of sclerotized injury) or stabilization of the atherosclerosis (delay of development of sclerotization and/or suppression of the formation of new sclerotized injury). A phosphate-substituted amino acid or imino acid, a proline derivative, a mercaptoacyl derivative of a substituted proline, a carboxyalkyldipepide derivative, etc., are used as the ACE inhibitor and applicable to both a patient suffering from hypertension and a patient with a normal blood pressure. The dose thereof is within the range of about 0.01-100mg/kg, preferably about 0.1-25mg/kg in the case of oral administration and within the range of about 0.005-10mg, preferably about 0.01-1mg/kg in the case of the parenteral administration. n COPYRIGHT: (C)1991,JPO |