| abstract |
NEW MATERIAL: A compound of formula I {R 2 is a metal ion, H, etc.; R 3 is a metal ion or lower alkyl; R is R 1 -(CH 2 ) n - or R 1 -(CH 2 ) m O- [n is 1-4; m is 0-3; R 1 is R 5 -Q 1 -Q 2 -Q 3 - (Q 1 -Q 3 is -CH 2 -C≡CH 2 -, a single bond, etc., provided that when Q 1 is a single boind, then Q 2 and Q 3 are each a single bond, and when Q 2 is a single bond, then Q 3 is a single bond; R 5 is formula II, formula III, etc.; R 16 is H or lower alkyl; p is 2-7)], etc.}. n EXAMPLE: (E,E)[Ethoxy(5,9,13trimethyl-4,8,12tetradecatrieny) phosphinyl]formic acid ethyl ester. n USE: Anti-hypercholesterolemia or anti-atherosclerosis agents. n PROCESS: A compound of formula IV is mesylated to give a compound of formula V, which is treated with a metal halide. Then, the product is subjected to Grignard reaction and then reacted with a compound of the formula ClP(OR 2a ) 2 (R 2a is lower alkyl). Finally, the product is reacted with a compound of the formula ClCO 2 R 3a (R 3a is R 2a ). n COPYRIGHT: (C)1991,JPO |