| abstract |
NEW MATERIAL:A phenoxypropylamine derivative expressed by formula I [R 1 and R 2 are lower alkyl or R 1 and R 2 together may form (CH 2 ) n (n is 4 or 5); R 3 is lower alkyl, lower alkoxy or halogen; X is -O- or -S-; Y is -NH- or -O-; m is 1-5] or salts thereof. n EXAMPLE: N-{3-[3-(Piperidinomethyl)phenoxy]propyl}-2-[2-(benzimidazolyl) thio]acetamide. n USE: Useful as an antiulcer agent, capable of inhibiting acid secretion, promoting treatment of ulcer and further preventing recurrence after discontinuing administration by powerful enhancing action on protective factors and used as a remedy for gastric ulcer, etc. n PREPARATION: A chloro derivative expressed by formula II is reacted with a thiol (or alcohol) derivative expressed by formula III in the presence of a base such as sodium hydroxide to afford the compound expressed by formula I. n COPYRIGHT: (C)1991,JPO&Japio |