| abstract |
PURPOSE: To reverse the effects of glucocorticoid-induced skin atrophy by topically administering a retinoid. n CONSTITUTION: This method for reversing the effects of glucocorticoid-induced skin atrophy comprises topically administering to the glucocorticoid-treated skin a pharmaceutical composition comprising an effective amount (usually 0.00001-3.0wt.%) of a retinoid and a pharmaceutically acceptable carrier. The retinoid includes all trans-retinoic acid, 13-cis-retinoic acid, (all E)-9-(4- methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid ethyl ester. The composition is applied before, when or after the glucocorticoid is coated. n COPYRIGHT: (C)1991,JPO |