http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H03135983-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-00 |
| filingDate | 1990-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c9cd77b2a7aff62b19d509156dd9b3fd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26dae1d784d176e812eecbb5a87ba164 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7e0fd8bee2925c4bfab8d94b3e0fa50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e84c3dc89abdbafe4a21d2d356a3eb7b |
| publicationDate | 1991-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H03135983-A |
| titleOfInvention | Production of 1,1-dioxo-7-substituted cephems |
| abstract | PURPOSE: To provide the subject cephem compound as elastase inhibitor useful for antiinflammatory and anti-denaturation agents, by oxidising a specified compound, diazotising the oxidised product, treating the product with trifluoroacetic acid, etc., converting the product into an acid halide and condensing the product. n CONSTITUTION: A compound of formula I [R 3 is (phenyl)C 1-6 alkoxy, allyloxy, C 1-6 alkoxycarbonyl-C 1-6 alkoxy] is oxidised using an aqueous hydrogen peroxide and sodium tungstate as a catalyst, thereby to give a compound of formula II. The product is diazotized and the diazo moiety is reduced with RH to give a compound of formula III. When the group R 1 is other than R 3 , the compound of formula III (R 3 is t-butoxy) is treated with trifluoroacetic acid, or the compound of formula III (R 3 is allyloxy) is treated with (Ph 3 P) 4 Pd and formic acid, thereby to yield a compound of formula IV. The product is converted into a corresponding acid halide, which is condensed with R 1 H to give an objective compound of formula V (R is C 1-6 alkoxy, etc.; R 2 is C 1-6 alkyl, etc.). n COPYRIGHT: (C)1991,JPO |
| priorityDate | 1989-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.