| abstract |
PURPOSE: To provide a method for the production of carbocyclic guanosine useful as synthetic intermediates for carbocyclic nucleoside analogs used as antiviral agents, by hydrolysing aristeromycin derivative in single step under mild conditions. n CONSTITUTION: A compound of formula I (R 1 is C 1-4 alky or aryl-C 1-4 alkyl; R 2 to R 4 are each H or OH-protecting group) is hydrolysed with an inorganic acid such as hydrochloric acid, nitric acid, sulfuric acid, etc., at -10 to 120°C, preferably 80 to 120°C and the protecting group is optionally removed to give an objective compound of formula II. n COPYRIGHT: (C)1991,JPO |