| abstract |
NEW MATERIAL: A compound of formula I [Ar 1 is optionally substd. phenyl or naphthyl; A 1 is C 1-6 alkylene, C 3-6 alkenylene, etc.; Ar 2 is phenylene or 6-membered heterocycle; R 1 and R 2 together form -A 2 -X-A 3 - (A 2 and A 3 are each C 1-6 alkylene; X is oxy, thio, etc.); R 3 is C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, etc.], and its salt. n EXAMPLE: 4-ethyl-2,2-dimethyl-4-[3-(napht-2-ylmethoxy)phenyl]-1,3-dioxolane. n USE: Inhibitors of the enzyme 5-lipoxygenase and useful for asthma symptomatic allergy, allergic rhinititis, psoriasis, atopic skin disease, etc. n PROCESS: A compound of formula II is alkylated with a compound of the formula A 1 -A 1 -Z (Z is a removable group) and the protecting group is optionally removed to give the compound of formula I. n COPYRIGHT: (C)1991,JPO |