| abstract |
NEW MATERIAL:A compound expressed by formula I (R 1 is amino or acylamino; R 2 is H or methoxy; R 3 is H; R 4 is vicinal dihydroxylated aryl; R 5 is lower alkylene; R 6 is H, carboxy-protecting group or linked to Y - to form negative charge; X is O, S or sulfinyl; Y - is counter ion of pyridinio group). n EXAMPLE: 3-(1-(3,4-Dihydroxyphenacyl)pyridinio-4-yl)thiomethyl-7β-(2-(2- aminothiazol-4-yl)-2-(1-carboxy-1-methylethoxy)iminoacetamide)-3-cephem-4- carboxylate 1-oxide. n USE: An antimicrobial agent for preventing and treating susceptible infectious diseases. n PREPARATION: For example, an amine expressed by formula II is used as a raw material, amidated and then subjected to heterocyclic group thiation, pyridinio formation, deprotection, esterification, sulfoxidation, sulfoxide cyclization or salt formation. n COPYRIGHT: (C)1991,JPO&Japio |