| abstract |
NEW MATERIAL: A compound of formula I (R 1 is lower alkyl, etc.; R 2 is H, lower alkyl, etc.; R 3 is substd. phenyl, etc.) or its acid addition salt, and an imidazolium salt of formula II (R 4 is lower alkyl or aralkyl; W is formula III, etc.; X is an anion), and a compound of formula IV (W' is formula V; Z is an anion). n EXAMPLE: 1,3-Dimethyl-2-{[3-([1-methyl-1H-imidazol-2-yl]thio)-2-oxopropyl]thio}-1 H-imidazolium. n USE: Useful as transglutaminase inhibitors for thrombolytic therapy. n PROCESS: One mole of a compound of formula VI is reacted with 1,3- dichloroacetone in the presence of a tertiary amine, then with an alkali metal salt of a mercaptoheteroaryl compound to give the compound of formula I. n COPYRIGHT: (C)1991,JPO |