http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H03118354-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6831b19bfc354357342f7c7da79fc162 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-24 |
| filingDate | 1989-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6f390c2ef43821095642b16d2d8aaa5c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97c4afa61cbf1041d719b07f1f96fa6b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_93d83081d6cbc598e1d018e5543c07ca http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_024442edc7b97fc2e97a7a72a3ba8aaf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_70244f47278c9dee1f22e3663c777028 |
| publicationDate | 1991-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H03118354-A |
| titleOfInvention | Production of aspartic acid 4-benzyl ester |
| abstract | PURPOSE: To easily obtain the subject compound useful as a synthetic intermediate for pharmaceutical compound with simple operation on an industrial scale at a low cost in high yield without using copper compound by partially hydrolyzing an aspartic acid dibenzyl ester with a base. n CONSTITUTION: The objective compound useful as aspartyl-seryl-aspartyl-prolyl- arginyl, etc., which is a polypeptide having excellent antiallergic action can be produced by partially hydrolyzing (A) 1 mol of aspartic acid benzyl ester derived from aspartic acid and benzyl alcohol or its salt such as p- toluenesulfonic acid salt with (B) 1.8-2.4mol (especially preferably 2.0-2.2mol) of a base such as NaOH or KOH in a mixture of an organic solvent (e.g. tetrahydrofuran or acetone) and water at 0°C to room temperature, preferably 0-150°C. n COPYRIGHT: (C)1991,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6371886-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1391449-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7891266-B2 |
| priorityDate | 1989-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 58.