| abstract |
NEW MATERIAL: A compound of formula I [R 1 is a (fluorinated) lower alkyl; R 2 is H, a (fluorinated) lower alkyl or lower alkenyl; X is a lower alkylene, oxy, thio, or direct bond; alk is a lower alkylene; (n) is 1 or 2; R 3 is a (chlorinated) polyfluoro-lower alkyl; R 4 is an (esterified, amidated) carboxy, or 5- tetrazolyl; R 5 is H or a lower alkyl]. n EXAMPLE: 7-[(6R,7S)-2,2,3,3,3-pentafluoro-6-hydroxy-14-(4-acetyl-3-hydroxy-2- propylphenoxy)tetradeca-8(E), 10 (Z)-dien-7-ylthio]-4-oxo-4H-1-benzopyrane-2- carboxylic acid methyl ester. n USE: A leukotriene antagonism drug. n PREPARATION: Epoxide of formula II is reacted with thiol of formula III. n COPYRIGHT: (C)1991,JPO |