| abstract |
PURPOSE: To obtain an aqueous preparation which is used as eye drops free from local stimulation with high storage stability by using a specific concentration of a pyrido[1,2-a]pyrimidine derivative, a specific concentration of polyoxyethylene sorbitan fatty acid ester, polyethylene glycol or the like. n CONSTITUTION: The subject preparation contains 0.1 to 0.3W/V% of a compound of the formula (R is n-propyl, allyl; A is tetrazolyl, carboxyl; n is 0 to 2), 0.5 to 2.0W/V% of polyoxyethylene sorbitan fatty acid ester, 0.5 to 2.0W/V% of polyethylene glycol and 1.0 to 3.5W/V% of sodium hydrogen phosphate. The preparation does not form crystals even when stored at room temperature or in a cooled place for a long period of time without decomposition of the compound of the formula. n COPYRIGHT: (C)1991,JPO&Japio |