| abstract |
NEW MATERIAL:A compound expressed by formula I [R 1 and R 2 are H, lower alkyl, (substituted) phenyl, (substituted) naphthyl, etc.) R3 is lower alkyl; X is O or S]. n EXAMPLE: 4-Diethoxyphosphinoylmethyl-N-(5-methyl-3-isooxazolyl)-benzamide. n USE: A remedy and preventive for hypercholesterolemia, hypertriglyceridemia, hyperphospholipemia, hyper-free fatty acidmia, etc., as a remedy for hyperlipemia. n PREPARATION: A carboxylic acid derivative expressed by formula II is reacted with amines expressed by formula III, preferably at equimolar ratio in the presence of a condensing agent A (preferably diethylphosphoric acid cyanide is used together with triethylamine) to provide the compound expressed by the formula I (group X is 0). n COPYRIGHT: (C)1991,JPO&Japio |