| abstract |
NEW MATERIAL:(+) or (-)-trans-4,5-Bis-[bis(4-methoxy-3,5-dimethylphenyl) phosphinomethyl]-2,2-dimethyl-1,3-dioxolan expressed by the formula (* is asymmetric carbon). n USE: Useful as an intermediate for medicine, e.g., optically active lignanes and catalyst ligand of asymmetric hydrogenation reaction in producing β-benzyl-γ- butylolactone derivative. n PREPARATION: (-) and (+)-trans-4,5-Bis(tosyloxymethyl)-2,2-dimethyl-1,3-dioxolan obtained from diethyl L-(+)- and D-(-)-tartrate is reacted at low temperature with lithium phosphide obtained by treating bis(4-methoxy-3,5-dimethylphenyl) phosphine which is a novel substance with normal butyllithium. n COPYRIGHT: (C)1990,JPO&Japio |