| abstract |
NEW MATERIAL: A compd. represented by formula I (wherein R 1 is a group represented by formula II, N 3 or the like; R 2 is H or a nitrogen protective group capable of being removed by hydrolysis, etc., R 5 is H or an OH protective group capable of being removed by hydrolysis, etc.; one of R 3 and R 4 is H and the other one of them is CH 3 ; and R 2 and R 5 can together form a 6-membered heterocyclic ring). n EXAMPLE: (±)-3S-azide-4R-(1S-methyl-2-t-butyldiphenylsilyloxyethyl)-azetidin-2-one. n USE: An antibacterial agent. n PROCESS: A compd. represented by formula III is treated with P-anisidine represented by formula IV to obtain an imine represented by formula V and this compd. is treated with azidoacetyl chloride and triethylamine in methylene chloride to obtain a compd. represented by formula VI. Next, this compd. is treated with ammonium cerium nitrate at 0°C to obtain the designated compd. wherein R 1 is N 3 -, R 2 is H and R 5 is t-butyldiphenylsilyl. n COPYRIGHT: (C)1990,JPO |