http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H0278695-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_44c713790ce00813da2e6c6d57a29456 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7042 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H17-08 |
| filingDate | 1988-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b80b6342c666b7915fab011390cab231 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_51addb364e4adc303e547427e61bd4aa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2ad73e3c7b8547a0c95c08ca8066544 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d55fce695093ce7a7ca1ec1fb653d1f3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b1b66cd60cf2a48f4d933284757daaa4 |
| publicationDate | 1990-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H0278695-A |
| titleOfInvention | Erythromycin derivative |
| abstract | NEW MATERIAL:12-Di-O-methylerythromycin A and 6-O-(methyl-12-O- methylthiomethyl) erythromycin A of the formula and salts thereof. n USE: An antibiotic. The erythromycin derivatives of the formula exhibit improved absorbing property and tissue-transferring property. n PREPARATION: 6-O-Methylerythromycin A is reacted with allyl chloroformate to give 2-O,3-N-bis(allyloxycarbonyl) derivative, which is reacted with a trimethylsilylating agent in an inactive solvent to prepare 4"-O-trimethylsilyl derivative. The derivative is reacted with allyl bromide in the presence of a base in an aprotic dipolar solvent and the resultant 11-O-allyl derivative is reacted with a methylating agent in the presence of a base to give a 12-O-methyl derivative. The 12-O-methyl derivative is reacted with palladium acetate and triphenyl phosphine in the presence of formic acid (salt) and the reaction product is subjected to a reductive N-methylation reaction using formaldehyde and formic acid to regenerate the dimethylamino group. n COPYRIGHT: (C)1990,JPO&Japio |
| priorityDate | 1988-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 43.