| abstract |
PURPOSE: To obtain a medical composition having excellent compatibility with drug and excellent biodegradation by reacting a polymer of lactic acid and/or glycolic acid with polyethylene glycol to give a copolymer as a base and adding polypeptide to the base. n CONSTITUTION: A polymer or copolymer (one having 400-5,000 number-average molecular weight is used) of lactic acid and/or glycolic acid is melted under heating at 100-250°C, softening point thereof. Then the melted polymer or copolymer is reacted with polyethylene glycol (one having 200-2,000 number-average organic is used) under a nitrogen gas introduction to give a copolymer. Then copolymer is used as a base and mixed with polypeptide. In blending, for example, an aqueous solution or hydrogel of the copolymer is mixed with powder of an aqueous solution of the polypeptide. n COPYRIGHT: (C)1990,JPO&Japio |