| abstract |
NEW MATERIAL: A compd. represented by formula I [wherein X 1 to X 6 are each CH or N; but at least one of X 1 to X 3 and X 4 to X 6 is CH; Y is NR 5 (R 5 is H or a lower alkyl), O or S; Z is NR 6 (R 6 =R 5 ), O or S; R 2 and R 4 are each R 5 or R 6 ; R 1 and R 3 are each H, a lower alkyl, cycloalkyl, aryl-lower alkyl, aryl, free or functionally deformed carboxy, OH or etherified OH], its tautomer and its salt. n EXAMPLE: 2,2'-Diamino-4,4'-bipyridine dihydrochloride. n USE: A medicine. An antitumor agent. This new material has strong specific inhibition action especially against enzyme S-adenosylmethionine decarboxylase and used for treating a benign or malignant tumor and also used for treating pneumonia brought about by the treatment of protozoiasis. n PROCESS: W 1 and W 2 of a compd. represented by formula II (W 1 and W 2 are groups represented by formulae III, IV) are respectively converted to the groups represented by formulae III and VI to obtain the compd. represented by the formula I. n COPYRIGHT: (C)1990,JPO |