http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H0272129-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f8dbdfc93841b3d731fbab7ea48b412a |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C29-147 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C29-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C29-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C27-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C29-132 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C29-147 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C31-10 |
| filingDate | 1989-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40a28cf13ae5b9caddb6a5c2a6a2348b |
| publicationDate | 1990-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H0272129-A |
| titleOfInvention | Preparation of enantiomerically pure 1,2-propanediol |
| abstract | PURPOSE: To obtain an enantiomerically pure 1,2-propanediol useful in the preparation of a Ca blocker of verapamil and gallopamil by reacting L(-)-lactide or D(+)-lactide with a reducing agent and isolating the product. n CONSTITUTION: L(-)-Lactide or D(+)-lactide is reacted with a reducing agent (e.g. diisobutylaluminum hydride, triethoxy-silane) in an inert solvent (e.g. toluene, heptane) at 40-70°C and alkali-hydrolyzed, and then, the inert solvent is removed from the aqueous solution to separate precipitated Al(OH) 3 . Subsequently, the aqueous phase is condensed by evaporation and the residue is suspended in a suitable solvent to separate a solid reaction product by filtration and the solvent is removed, and then, the filtrate is distilled to obtain an enantiomerically pure 1,2-propanediol. n COPYRIGHT: (C)1990,JPO |
| priorityDate | 1988-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.