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filingDate 1988-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4b036c2d5e4d7735d248501ba3bef2b0
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publicationDate 1990-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-H0267259-A
titleOfInvention N-acyl-gamma-aminobutyric acid and production thereof
abstract NEW MATERIAL:A compound shown by the formula (R-CO- is acyl). n EXAMPLE: N-Palmitoyl-γ-aminobutyric acid. n USE: Capable of efficiently transporting γ-aminobutyric acid slightly to be passed through blood-brain barrier to cerebral tissue and being expected to promote acetylcholine metabolism of γ-aminobutyric acid, to improve glucose using ability and to have activating effects on cerebral functions. Improving action of γ-aminobutyric acid on hypertension and on subjective symptom followed by hypertension is expected to rise by introducing a highly unsaturated fatty acid of ω-3 base into acyl group to be introduced into γ-aminobutyric acid. n PREPARATION: 1mol fatty acid is dissolved in anhydrous tetrahydrofuran, a nitrogen-containing heterocyclic compound such as imidazole or carbonyldi- imidazole is added as a basic catalyst and γ-aminobutyric acid is added and the reaction is carried out to give a compound shown by the formula. The whole reaction is done at room temperature. n COPYRIGHT: (C)1990,JPO&Japio
priorityDate 1988-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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