| abstract |
PURPOSE: To obtain the subject composition capable of alleviating contraction function insufficiency and reducing tissue necrosis, by administration during both coronary atresia and reperfusion periods or during only a perfusion period, comprising a potassium tube activator. CONSTITUTION: This composition comprises a potassium tube activator, has inhibitory effects on spontaneous mechanical activity preferably at a rat portal vein, namely <=2μM IC50 and is composed, for example, of (+)-2-cyano-1-(4- pyridyl)-3-1(1,2,2-trimethylpropyl)guanidine and (±)-6-cyano-3,4-dihydro-2,2- dimethyl-trans-4-(2-oxo-1-pyrrolidyl)-2H-benzo[b]-pyran-3-ol. Preferably, the composition is locally administered to a coronary arteries by arterial vascular contrastradiography or injection in a corona by a catheter and its dose is 0.001-30mg/kg/time, preferably 0.5-25mg/kg/time. |