| abstract |
NEW MATERIAL:A (2-alkylmalonato)(2-alkyl-1,3diamino-propane)platinum(II) expressed by formula (R 1 represents 1-4C alkyl; R 2 represents H or 1-4C alkyl). n EXAMPLE: (Malonato)(2-n-propyl-1,3-diaminopropane) platinum(II). n USE: A carsinostatic agent with a low toxieity. n PREPARATION: A(dichloro)(2-alkyl-1,3-diaminopropane)platinum(II) expressed by formula II is passed through an ion-exchange resin regenerated with sodium hydroxide to afford a (dihydroxy)(2-alkyl-1,3-diaminopropane)platinum(II), which is dissolved in water and malonic acid or a 2-alkylmalonic acid expressed by formula IV is added and reacted therewith at room temperature for 24hr while stirring. n COPYRIGHT: (C)1990,JPO&Japio |