| abstract |
PURPOSE: To obtain a blood platelet adhesion inhibitor containing a benzazole compound or a salt thereof as an active ingredient. n CONSTITUTION: The objective substance obtained by making a benzazole compound expressed by formula I [X is S or formula II (R 3 is H, lower alkyl, etc.); R 1 is halogen, cyano, cyano-substituted lower alkoxy, etc.; R 2 is pyrrolyl or thienyl which may be substituted with lower alkyl, lower alkoxy which may have halogen as a substituent group on the phenyl ring, etc.; n is 0-2] or a salt thereof in an amount of 1-70wt.% based on the total composition contain, mixing normally used pharmaceutical ingredients therewith and formulating a pharmaceutical according to a conventional method. The inhibitor can be prepared in a form, such as tablet for oral administration, injection or suppository, and the dose thereof is 0.06-100mg/kg/day compound expressed by formula I. The compound expressed by formula I is obtained by reacting a compound expressed by formula III R 14 is halogen) with a compound expressed by formula IV (R 10 and R 11 are H, lower alkyl, phenyl, etc.). The compound expressed by formula I is useful for arteriosclerosis, ischemic cardiopathy, nephritis or in artificial dialysis, imbedding artificial organs, etc. n COPYRIGHT: (C)1990,JPO&Japio |