| abstract |
NEW MATERIAL:A compound expressed by formula I {R 1 is formula II to IV [R 4 is lower alkyl; R 5 is (protected) amino]; R 2 is lower alkoxymethyl, lower alkylthiomethyl, etc.; R 3 is (protected) carboxy; A is (substituted) lower alkylene which may have a substituent group selected from the group consisting of amino, protected amino, hydroxy, oxo and =N-OR 6 , provided that R 6 is not lower alkyl when R 2 is lower alkoxymethyl}. n EXAMPLE: Benzhydryl 7-[N-tert-butoxycarbonyl-2-(3-methanesulfonamidophenyl)-D- glycinamido]-3-methylthiomethyl-3-cephem-4-carboxylate. n USE: An antimicrobial agent against Gram-positive and Gram-negative bacterial for oral administration. n PREPARATION: A compound expressed by formula V, a reactive derivative at the amino group or salt thereof is reacted with a compound expressed by the formula R 1 -A-COOH, a reactive derivative at the carboxy group or salt thereof. Furthermore, the compound expressed by formula V is a novel substance. n COPYRIGHT: (C)1990,JPO&Japio |