| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aa67eb74ea5b96d9f8f2cfdb3b025770 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4465
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4433
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-443
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4427
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4468 |
| filingDate |
1990-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a582701100f27fe262739f42c7f509ac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8dfd73e9f2eb49bd81d59737b0b4e6e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_00719461b9a7a3003467fc8b1d106e6d |
| publicationDate |
1990-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-H02292259-A |
| titleOfInvention |
Production of 4-alkoxyalkyl-4-aminophenylpiperidine and its derivative |
| abstract |
PURPOSE: To obtain the subject compound useful as an analgesic for intravenous injection or an anesthetic by reacting an N-substituted 4-piperidone compound with an anionic reagent and reducing the product with a reducing agent. n CONSTITUTION: An N-substituted 4-piperidone compound is reacted with an aniline compound to form a Schiff base compound, and this is reacted with an anion-stabilizing group-containing anionic reagent represented by the formula [wherein X is an anion stabilizing group; Y is H or a lower alkyl; Z is a lower alkoxyl or phenylmethoxyl; and M is an alkali or (alkaline earth) metal] to obtain an amine compound. This is reduced with a reducing agent (e.g. metal hydride or Raney nickel) to stabilize the anion stabilizing group to obtain a 4-alkoxyalkyl-4-aminophenylpiperidine. Suitable examples of the anionic reagents include methoxymethylphenyl sulfide and an α-Li derivative thereof, etc. n COPYRIGHT: (C)1990,JPO |
| priorityDate |
1989-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |