| abstract |
NEW MATERIAL: A compound of formula I [R 1 is H or methyl; R 2 is ethyl, propyl, imidazol-2-yl, ethoxycarbonyl or the like; R 3 is isobuthyl, benzyl or the like; A is formula II (R 5 is phenyl, naphthyl or the like; and R 6 is H, an alkoxycarbonylalkyl or the like), -Y-Z (Z is phenylglycine, cyclohexylalanine, tyrosine or the like); and R 4 is an alkanoyl, an arylcarbonyl or the like]. n EXAMPLE: (S)-N-[1S,2S,4S]-1-(Cyclohexylmethyl)-2-hydroxy-4-isopropyl-5- oxodecyl]-α-[(R)-α-(3,3-dimethyl-2-oxobutyl)hydrocinnamamide]imidazole-4- propionamide. n USE: A pharmaceutical preparation for controlling or preventing hypertension and cardiac insufficiency. n PREPARATION: For example, a compound of formula III is reacted with a compound of formula IV to obtain a compound of formula I. n COPYRIGHT: (C)1990,JPO |