http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H02282372-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f9ba304908c7187b486482f16a0f6158 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-42 |
| filingDate | 1989-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_01ff46a951a7c4529f30ac5efb682ba4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38051a7c9098b48ce0925ec50025c89f |
| publicationDate | 1990-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H02282372-A |
| titleOfInvention | Production of o-acylthiamine disulfides |
| abstract | PURPOSE: To obtain the title compound which is useful as a preventive or remedy for vitamin B 1 deficiency at lowered temperature in a shortened time in high yield by reaction of thiamine disulfide and a carboxylic anhydride in the presence of 2-dimethylaminopyridine. n CONSTITUTION: The reaction of thiamine disulfide(TDS) with 1 to 1.2 equivalent amount, based on the TDS, of a carboxylic anhydride is carried out, preferably in the presence of 0.5 to 10wt.%, based on the TDS, of 4-dimethylaminopyridine, usually in an organic solvent, preferably chloroform, methylene chloride at 20 to 80°C, preferably 20 to 40°C to give O-acylthiamine disulfide (a vitamin B 1 derivative) without discoloration and decomposition product, thus in no need of decoloration process with extreme advantage industrially and economically. n COPYRIGHT: (C)1990,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108191773-A |
| priorityDate | 1989-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 35.