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filingDate 1989-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_872ac9b7b5fe6bd82e6953074c26927e
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publicationDate 1990-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-H0228194-A
titleOfInvention Pregnane derivative
abstract The present disclosure is directed to a process and intermediates for the synthesis of Vitamin D3 metabolites such as 1,25-dihydroxycholecalciferol, 25-hydroxycholecalciferol and 24R,25-dihydroxycholecalciferol from 17-keto steroids via intermediates having the natural steroid configuration at the 20-position. These novel intermediates are prepared from 17-keto steroids by reaction with ethyltriphenylphosphonium halides followed by reaction with formaldehyde to form comounds having the natural steroid configuration at the 20-position and which are suitable substrates for the preparation of the aforementioned Vitamin D3 metabolites.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102511369-A
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