| abstract |
NEW MATERIAL:A compound expressed by formula I [R 1 is H, (carboxy substituted) lower alkyl or oxopyrrolidyl; R 2 is phenyl having 1-3 substituent group such as OH; A is formula II or formula III, whose N-6 membered ring part is occasionally substituted by ≤2 carboxyl groups : B is bond hand, -CH 2 -, -CH 2 -CH 2 - or formula IV]. n EXAMPLE: 7β-[2-(2-Aminothiazol-yl)-2(Z)-(2-carboxypropyl-2-oxyimino) acetamide]-3-[1-(3,4-dihydroxyphenyl)-4-pyridinio]thiomethyl-3-cephem-4- carboxylate monosodium salt. n USE: An antimicrobial agent. n PREPARATION: A compound expressed by formula V [R 3 is (protected)amino; X 1 is reactive residue] is reacted with a thiopyrrolidone expressed by formula VI or thiopyridine expressed by formula VII. n COPYRIGHT: (C)1990,JPO&Japio |