| abstract |
NEW MATERIAL:A compound shown by formula I [R 1 is H, lower alkyl, halogen, etc.; R 2 is H, lower alkyl, etc.; X is -O- or -S-; Y is single bond, lower alkylene, etc.; Z is lower alkylene, etc.] and a salt thereof. n EXAMPLE: N-(2-Nitroxyethyl)-4-thiazolecarboxamide. n USE: A vasodilator having vasodilating action on blood vessel and long durability. n PREPARATION: According to the reaction formula, a compound shown by formula II or a reactive derivative at the carboxyl group thereof or a salt thereof is reacted with a compound shown by formula II or a reactive derivative at the amino group thereof or a salt thereof to give a compound shown by formula I or a salt thereof. n COPYRIGHT: (C)1990,JPO&Japio |