| abstract |
NEW MATERIAL:A compound expressed by formula I {Rf is formula II [X is H or halogen; R 1 is formula III (R 2 is H, OH, 1 to 3C alkyl, etc.), formula IV, etc.] or formula V [R 3 is H or 1 to 3C alkyl; (p) is 0 to 2; Z' is Z (Z is H, amino, OH, etc.); (r) is 1 to 3; (s) is 0 or 1; (t) is 0 to 4; provided that when (p) is 0, (s) is not 0 and at least one of X is F]}. n EXAMPLE: 3-[3'-(2"-Nitroimidazolyl-2',2'-difluoropropyonylamino] propionic amide. n USE: A medicine and radiation sensitizer. The compound expressed by formula I has low toxicity and low neurogenicity and promotes inactivation by radiation irradiation of a cell existing in a malignant tumor and being difficult to cure and low in oxygen. n PREPARATION: For example, a compound expressed by the formula NI-H (NI is formula VI) is reacted with a compound expressed by formula VII (A is R 1 ) to give a compound expressed by formula VIII, which is fluorinated with a fluorinating agent such as diethylamino-sulfurtrifluoride to provide the compound expressed by formula I. n COPYRIGHT: (C)1990,JPO&Japio |