| abstract |
NEW MATERIAL:The compound of formula I (R 1 is lower alkoxycarbonyl or 212C alkylcarbamoyl; R 2 is lower alkyl or phenyl when R 1 is lower alkoxycarbonyl; R 3 is H, 2-12C alkoxycarbonyl, alkylcarbamoyl, etc.; when R 1 is alkylcarbamoyl, R 2 and R 3 are lower alkoxy-carbonyl) or its acid addition salt. n EXAMPLE: 9-Ethoxycarbonyl-2-methoxycarbonyl-7-phenyl-4,5-dihydro-4,5-dioxo-1H- pyrrolo[2,3-f]quinoline. n USE: A drug. A 5-lipoxygenase inhibitor or a lipid peroxidation preventing agent. It has low toxicity and is useful for the prevention and remedy of allergy, coronary and cerebral circulation disorder, etc. n PREPARATION: The compound of formula I can be produced by carrying out oxidative demethylation reaction of a compound of formula II with an oxidative demethylation agent such as cerium(IV) ammonium nitrate. n COPYRIGHT: (C)1990,JPO&Japio |