| abstract |
NEW MATERIAL: Compds. of formula I (wherein R 1 is H, lower alkyl or benzyl; R 2 is H, OH or lower alkanoyloxy; R 3 is H or lower alkyl; R 4 is H or halogen; R 5 is H, acyl, methyl or benzyl; m is 0 or 1; and n is 2 to 10) and salts thereof. n EXAMPLE: 4-[6-(6,7-Dihydroxy-2-naphthalenyl)hexyloxy]-2-hydroxy-3-propylbenzoic acid. n USE: Treatment of inflammatory bowel diseases. n PROCESS: A compd. of formula II (wherein X is halogen; and R 6 is methyl, acyl or benzyl) is reacted with a compd. of formula III (wherein R 7 is lower alkyl or benzyl) in the presence of Na 2 CO 3 or the like in a solvent such as DMF at 40 to 70°C to obtain a compd. of formula I. n COPYRIGHT: (C)1990,JPO |