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filingDate 1989-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_25b04fcabd782a3504bf1da279ba4178
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publicationDate 1990-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-H02258721-A
titleOfInvention Pharmaceutical combination preparation containing nucleoside deriavative and rentosan polysulfate
abstract PURPOSE: To obtain a combination preparation containing a specific nucleoside derivative and a pentosan polysulfate and having a especially remarkable activity against the infections of viruses, especially the infections of retro viruses. n CONSTITUTION: This combination preparation contains (A) a compound selected from compounds of formulas I-V [A, B are each CH, N; R 2 is H, NH 2 ; R 3 is R 2 , SH; R 4 is H, F, Cl; Z is a group of formula VI (X is O, CH 2 , CRαRβ; Y is N 3 , NH 2 , F, Cl, H, an alkyl; Rα is H, F; Rβ is Rα, OH; or when Rβ is H, Y and Rα are each a band), a group of formula VII; R, R' are each H, OH, CH 2 OH, N 3 , NH 2 , F, CL, or R, R' together form a bond on the adjacent C atom; (m), (n) are each 0, 1; (p) is 2-4] and (B) pentosan polysulfate preferably having an average mol.wt. of 3500-6500 dalton and a sulfation degree of 75-95%. The component A is preferably 3'-azido-3'-deoxythymidine, 2',3'-dideoxy- thymidine, etc. n COPYRIGHT: (C)1990,JPO
priorityDate 1988-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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