| abstract |
NEW MATERIAL:A compound of formula I {R 1 and R 2 are each H, alkyl, cycloalkyl, alkenyl, acyl, etc.; R 3 is H, alkyl or phenyl; A is of formula II, III or IV [R 4 is H, alkyl, alkenyl, alkynyl, etc.; R 5 is H, halogen, alkyl, OH, etc.; R 7 is H, OH, alkoxy. etc.; Y is single bond or NR 8 (R 8 is H or alkyl); p is 1-4; q is 0-2; s is 1-3; Het is heteroaryl]; H is of formula V-VII (R 6 is H, alkyl or acyl; X is O or S; r is 0-3), etc.}. n EXAMPLE: N-[1-(3-methylbenzyl)-4-methylhexahydro-1H-1,4-diazepin-6-yl]-1H- indazole-3-carboxamide. n USE: Antagonistic agent for serotonin 3(5-HT 3 ) receptor. n PREPARATION: For example, a compound of formula VIII is reacted with a compound of formula [Z 1 is (CH 2 ) r -OH, etc.] to obtain the corresponding compound of the formula I. n COPYRIGHT: (C)1990,JPO&Japio |