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filingDate 1989-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8906f06252982178f65c140663e905c5
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publicationDate 1990-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-H02250882-A
titleOfInvention New fluorescent labeling agent
abstract NEW MATERIAL:A 2-(2-oxazolyl)benzofuran derivative expressed by the formula [R 1 to R 4 represent H, OH or 1-3C alkoxy, or R 2 and R 3 together represent hydrocarbons (in this case 1-2 chain member can be replaced with an O atom); X represents haloformyl or carboxyl]. n EXAMPLE: 2-(5-Ethoxycarbonyl-2-oxazolyl)-5,6-methylenedioxybenzofuran. n USE: A fluorescent labeling agent. n PREPARATION: Ethyldiazopyrvate is reacted with chloroacetonitrile in benzene in the presence of a copper catalyst to form 2-chloro-5-ethoxycarbonyl-oxazole, which is then reacted with 4,5-methylenedioxysalycylaldehyde in DMF in the presence of potassium carbonate to form a 2-(2-oxazolyl) benzofuran derivative. The resultant ester derivative is hydrolyzed under alkaline conditions and the obtained free acid is treated with thionyl chloride. n COPYRIGHT: (C)1990,JPO&Japio
priorityDate 1989-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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