http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H02231494-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f6e960aa6ad2ba6401030159343ebe68 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-04 |
| filingDate | 1989-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eed1a723dbcc46d3dd209b5c8155eb55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c3ef64fda50cf25e9e10ab732da9dbf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_686c00fa0664990963c33689b0227ee3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_960949f176e2edeb0f2259ce2e1721f3 |
| publicationDate | 1990-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H02231494-A |
| titleOfInvention | Production of dimer alkaloids |
| abstract | PURPOSE: To obtain the title compound such as vinblastine having antitumor activity and useful as an anticancer agent by adding oxalic acid (salt), etc., inorganic anion source, trivalent iron source and hydride source to a specific compound used as a starting raw material in the presence of oxygen. n CONSTITUTION: Oxalic acid (salt) and/or malonic acid (salt), inorganic anion source (preferably Cl - , Br - , I - , SO, etc., except such an inorganic anion as to produce an insoluble iron salt such as CO), trivalent iron source (preferably hydrochloric acid salt, sulfuric acid salt or nitric acid salt) and hydride source (e.g. sodium borohydride) are added to a compound (e.g. anhydro-vinblastine) expressed by formula I (R 1 is H, lower alkyl or formyl; R 2 is lower alkoxycarbonyl or amide; R 3 is acetoxy or OH) and used as a starting raw material in the presence of oxygen to provide the aimed compound expressed by formula II (R 4 is OH and R 5 is Et or R 4 is Et and R 5 is OH). n COPYRIGHT: (C)1990,JPO&Japio |
| priorityDate | 1989-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.