http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H02229192-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5e3324a35e1615e6eede6df1be26b7dd |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-30 |
| filingDate | 1989-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6a7a3d7c02428a4ff54c9f70d333b6c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d94b6a498efa071a47875992a762984f |
| publicationDate | 1990-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H02229192-A |
| titleOfInvention | Preparation of purine derivative |
| abstract | PURPOSE: To inexpensively, readily provide the subject compound in a high yield by subjecting a 2,5-dihydrofuran derivative to an isomerization reaction in the presence of a transition metal complex as a catalyst, to a reaction with a purine compound, to the removal of a trimethylsilyl group and subsequently to the removal of a protecting group. n CONSTITUTION: A compound of formula I (R is benzoyl or benzyl) is isomerized in the presence of a transition metal complex [e.g. dichlorobis(benzonitrile) palladium] as a catalyst to prepare a 2,3-dihydrofuran derivative of formula II. The compound of formula II is reacted with a compound of formula III [X is O or NH; Y 1 is H or X-Si(CH 3 ) 3 ] preferably in a solvent such as dichloroethane in the presence of a catalyst such as hydrochloric acid and the reaction product is treated with water or a 1-3C alcohol to remove the trimethylsilyl group. The prepared compound of formula IV (Y 2 is H, OH or NH 2 ) is dissolved in water, if necessary, acidified and the solution is alkalinized, extracted with chloroform, etc., and crystallized with ethanol, etc., to provide the objective compound of formula V. n COPYRIGHT: (C)1990,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102958931-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9403864-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0502447-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011150512-A1 |
| priorityDate | 1989-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.