| abstract |
NEW MATERIAL:A compound expressed by formula I [R 1 is lower alkyl, thienyl, pyridyl or formula II (R 3 is H, halogen, lower alkyl, etc.; R 4 is H or halogen); R 2 is H, lower alkyl or phenyl; X is 0 or S; Y is O or NH; Z is N-methyl-3- pyrrolidinyl, (N-methyl-2piperidyl)methyl, N-methyl-3-piperidyl or formula III (R 5 is lower alkyl or benzyl; n is 0-2)]. n EXAMPLE: N-{3β-(8-Methyl-8-azabicyclo-[3,2,1]octyl)}-2-phenyl-4- thiazolecarboxamide.1/2 hydrate. n USE: 5-HT Antagonist. n PREPARATION: A compound expressed by formula IV [Q is atom (group)] capable of eliminating is reacted with an amine expressed by the formula Z-Y-H, salt thereof or alcohol thereof in the presence of a base in an organic solvent. n COPYRIGHT: (C)1990,JPO&Japio |