http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H02225479-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_116c851e729089df9a427027272fa290 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-64 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-68 |
| filingDate | 1989-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_afb07656ea4feed38900cba4d83eb6f9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cee2ae7617d5fac5528451d1015ef33b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc2128d6880fc6577beb699c0e2b351c |
| publicationDate | 1990-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H02225479-A |
| titleOfInvention | Preparation of chroman derivative and synthesis intermediate |
| abstract | PURPOSE: To obtain chroman derivatives by esterifying 2-methylphenol for the position 4 of which an electron-attracting group is substituted, 4 by using e.g. 2-bromo-2-methyl propionate, brominating the methyl, reacting the product with a nitrogenous heterocyclic ring and cyclizing the product. n CONSTITUTION: A compound of formula I (wherein Z is an electron-attracting group) is reacted with a compound of formula II (wherein Alk is CH 3 or C 2 H 5 ) to obtain a compound of formula III. If necessary, the compound of formula III (wherein Z=Br) is converted into one of formula III (wherein Z=CN), and the CH 3 is converted into CH 2 Br by treatment with N-bromosuccinimide in the presence of a catalyst under irradiation with ultraviolet rays, and the product is reacted with a compound of formula IV (wherein X is O or N=R; R is H, NO 2 or CN; and R 1 and R 2 may form a five or six-membered heterocyclic ring together with the -N-CX-) in the presence of a basic condensing agent in an inert solvent to obtain a compound of formula V. The compound of formula III and a compound of formula III in which the CH 3 groups are CH 2 Br or CH 2 N(R 1 )CXR 2 groups, are novel substances. The compound of formula V is useful as an antihypertensive. n COPYRIGHT: (C)1990,JPO |
| priorityDate | 1988-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.