http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H02212474-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1374dd16777534b65ad4422333245af8 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-90 |
| filingDate | 1989-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8c173b0244245a26f23ec4d1cf13bc8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7fa60d88d2ba55246568e9dbbf7a4d6a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7980bac3cc1c51f46c2de219993286b6 |
| publicationDate | 1990-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H02212474-A |
| titleOfInvention | Production of optically active 1,4-dihydropyridine derivative |
| abstract | PURPOSE: To obtain the title compound in high yield by reaction of a benzylidene-acetoacetic ester derivative with an optically active 2-aminocrotonic acid derivative in the presence of lithium amide followed by hydrolysis and reaction with an ammonium salt. n CONSTITUTION: A benzylidene-acetoacetic ester derivative of formula I (X, Y, Z are H, halogen, nitro where X, Y, Z do not represent H at a time: R 1 is lower alkyl) and an optically active 3-aminocrotonic ester derivative of formula II (R 2 is formula III: R 5 is lower alkyl, lower alkyloxy; R 6 is phenyl; n is 0, 1; R 3 , R 4 are lower alkyl; * is chiral center) are allowed to react in the presence of lithium amide, preferably lithium diisopropylamide at -80 to -70°C in an inert solvent. Then, the product is hydrolyzed, and allowed to react with an ammonium salt of formula IV (L is monovalent anion) to give the compound of formula V. n COPYRIGHT: (C)1990,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112679416-A |
| priorityDate | 1989-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.