| abstract |
NEW MATERIAL:A compound expressed by formula I and salt of said compound [R 1 is H or lower alkyl; R 2 is aromatic group; R 3 is H, lower alkyl or aromatic group; n is 3-7; R 4 is H, lower alkyl or acyl; A is the formula -(CH 2 ) 1 -(l is 0, 1 or 2), etc., B is cyclic group, etc.]. n EXAMPLE: 3,4-dihydro-6,7-dimethoxy-N-{5-[N-ethyl-N-(phenylmethyl) amino] pentyl} naphthalene-2-carboxylic acid amide hydrochloric acid salt. n USE: Preventive or curing agent of senile dementia or Alzheimer's disease, etc. Exhibits inhibiting action against choline esterase. n PREPARATION: A compound expressed by formula II (Z is OH or reactive group of carboxylic acid) is reacted with a compound expressed by formula III and salt of said compound to obtain the compound expressed by formula I, or a compound expressed by formula IV and salt of said compound are reacted with lower alkyl group or acyl group to obtain a compound expressed by formula V and salt of said compound (R 4 ' is lower alkyl or acyl). n COPYRIGHT: (C)1990,JPO&Japio |