http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H02204418-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a22da5b7dd6ed60a21538e5edb23e051 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0004 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-10 |
| filingDate | 1989-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e329e23fa31ed74f5fea6b55db30ec8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9829823eefbb1337fb3185e14d57e7e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86a5ce4ad1dd9a53bf6b06ccdf06f379 |
| publicationDate | 1990-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H02204418-A |
| titleOfInvention | Somatotropin preparation |
| abstract | PURPOSE: To obtain a preparation containing an effective amount of a stabilized polyol and a sufficient amount of a buffering agent to maintain the pH level within a specific range, with physical stability, chemical stability and biological activity maintained, and capable of controlledly releasing somatotropin over a long period. n CONSTITUTION: This somatotropin preparation contains (A) ≥10 (pref. ≥20)wt.% of biologically active somatotropin, (B) an effective amount (20-80wt.%) of a polyol such as glycerol or tris(hydroxymethyl)aminomethane, and (C) a sufficient amount of a buffering agent (e.g. histidine hydrochloride, alkali metal phosphate) to attain the pH level so as to maintain the biological activity of the somatotropin over a sufficiently long period (namely, between 4.5 and a greater value, either 7 or the isoelectric point of the somatotropin). It is preferable that a wetting agent such as a nonionic surfactant (e.g. a polyethoxylated sorbitan ester) is added in preparing this preparation. n COPYRIGHT: (C)1990,JPO |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H08503013-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2000504696-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2006503005-A |
| priorityDate | 1988-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 130.