| abstract |
NEW MATERIAL: A compd. (salt) represented by formula I [wherein R 1 is H, a (substd.) alkyl or (substd.) aryl, R 2 and R 3 are H, an alkyl or aryl, R 4 is OH or NH 2 , R 5 is the same as R 1 and forms a cyclic group along with R 1 , A and B are each a (non-)natural amino acid, X can be absent, or represents O, S or CO, and p and q are 0 or 1-4]. n EXAMPLE: 1-Cyclohexyl-6-(2-pyridyl)-2S-[N-[N-(piperadin-1-yl-carbonyl)-L- phenylalanyl-L-norvaryl]amino]-3S-hexanol. n USE: A therapeutic agent for hypertension and heart failure. n PROCESS: For example, a compd. represented by formula II is reacted with a carbonic acid deriv. represented by formula III (R 9 and R 10 are halogen or alkoxy) and the reaction product is reacted with amines represented by formula IV to obtain the compd. represented by the formula I. n COPYRIGHT: (C)1990,JPO |