http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H02201162-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1374dd16777534b65ad4422333245af8 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-563 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-535 |
| filingDate | 1989-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f4428975e8c4f7a53f41cd09fd09215 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_78c5bb7e40a2fa455553134a3d608c09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50bf2573d87ec93fd2060f88ec3b2b30 |
| publicationDate | 1990-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H02201162-A |
| titleOfInvention | Enzyme antibody complex, combination of complex/ antibody, kit and diagnostic method using them |
| abstract | PURPOSE: To measure TNF-α with high sensitivity by forming an anti-TNF-α antibody as an Fab' fragment and conjugating enzyme via a maleimide group with the SH group of the hinge part thereof and thereby forming the enzyme antibody complex. n CONSTITUTION: The enzyme is conjugated via the maleimide group with the SH group derived from the disulfide bond in the hinge part of the Fab' fragment of the anti-TNF-α antibody to form the complex. The combination of the complex/antibody which is ≤10 in the relative fluorescent intensity of a zero blank when TNF-α is measured with ELISA by using the above-mentioned complex prepd. from one of the antibodies of two kinds of the different anti- TNF-α as the 2nd antibody and the other antibody as the 1st antibody is used. The quantity of the TNF-α in a soln. (prescribed human bodily fluid, such as blood or urine) is exactly measured with the high sensitivity in such a manner. The measurement of the TNF-α quantity in the normal human serum and the measurement of the fluctuation in the TNF-α values in the diseases arising from various inflammatory symptoms are enabled. n COPYRIGHT: (C)1990,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6252053-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9413322-A1 |
| priorityDate | 1989-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 21.