| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f84747e8d08b1023763356d0e7d1db68 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S436-829
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T428-2984 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-227
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1278 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J13-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-22 |
| filingDate |
1989-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d30c465c4cbbc26593b23797cefe0a7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ee75cccdf872d573857281654a56327 |
| publicationDate |
1990-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-H02196713-A |
| titleOfInvention |
Liposome for effectively packing and controllably releasing amphipathic molecule |
| abstract |
PURPOSE: To efficiently pack an amphipathic medicine in a large packing amount simply and rapidly by forming the gradient of ammonium ion between an internal aqueous phase and an external aqueous phase of liposome. CONSTITUTION: A suspension of liposome is prepared in the presence of ammonium sulfate. The external aqueous phase of the prepared suspension is diluted with a proper salt or buffer solution or ammonia is removed from an external aqueous phase, a natural ammonia molecule is diffused from an inner aqueous phase to the external aqueous phase to form a gradient of ammonium from the inside to the outside and a gradient of pH from the outside to the inside between the internal aqueous phase and the external aqueous phase. Then a deprotonized amphipathic medicine is packed from the outside into the inside, bonded to a liberated protein left in the aqueous phase and accumulated in the liposome. When a reverse pH gradient state occurs, the bonded medicine is dissociated into a proton and the deprotonized medicine to release the deprotonized medicine or the liposome. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2006515578-A
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20190120319-A
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-4874547-B2
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-4874548-B2
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019244979-A1
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11413244-B2
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11446247-B2
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2005505602-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8524274-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-4833836-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2018521080-A |
| priorityDate |
1988-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |