| abstract |
PURPOSE: To provide a vaginal sappository improved in the absorbability of dehydroepiandrosterone sulfate(DHAS) salt and having excellent storage stability containing the DHAS, an amino acid and a hard fat. n CONSTITUTION: A hard fat having a hydroxyl group value of ≤50 is employed as a base agent, thermally method, homogeneously mixed with the salt of DHAS and an amino acid, poured in a mold by a constant amount and subsequently cooled to provide the objective agent. The hard fat is a mixture of glycerides whose constituting fatty acids are 8-18C straight chain saturated fatty acids The DHAS, the amino acid and the hard fat are compounded in a ratio of 1 pt.wt., 0.2-3 pts.wt. and 1-20 pts.wt., respectively. The vaginal sappository is administered in a pregnant woman of the pregnancy of 37-39 weeks 1-3 times a day at a dosage of 100-1500mg a time as the salt of DHAS. n COPYRIGHT: (C)1990,JPO&Japio |